Pharmacological effects
1. Anti-Amoeba Protozoa: Pulsatilla decoction and its saponins can inhibit the growth of dissolved amoeba in vitro and in vivo, but all require large doses. In vitro tests, decoction at 1:40, can completely inhibit the growth of amoebic; 1:60 when there has been a round of preencapsulated type in the culture, saponins can inhibit the protozoa at 1:200 Growth occurs at 1:500, and contraction of the preantral shape occurs. At 1:1000, trophozoites are found to have therapeutic effects on rats. Both decoction and saponin can effectively inhibit the growth of amoeba in the intestine of mice. The effective amount is 1.0g (crude drug)/kg (equivalent to 1/250-1/750 of imatinine hydrochloride). The dosage is reduced to When 0.3g/kg, the effect is not obvious.
The Potentilla, which is often mistaken for Pulsatilla in the market, also has a certain effect on the in vitro or animal in vivo tests of dissolved amoeba, but it requires a large dose (3 times more than Pulsatilla). As for other misuses of Pulsatilla chinensis (Rosaceae), white drum nails (Caryophyllaceae), Rhynchophylla variegata, and autumn rat grass (Asteraceae), there is no anti-amoebic action in vivo and in vitro.
2, anti-trichomonas vaginalis: Pulsatillae in vitro anti-trichomonas vaginalis test, 60% of the extract or water at 5% concentration in 5 minutes to kill trichomoniasis, flow extract on vaginal mucosa irritation , However, acetone and diethyl ether were used to extract some of the stimulants in small amounts, and it is still valid for trichomoniasis. It is reported that the MIC of pulsatilla pneumophila is 2 mg/ml.
3, antibacterial effect: Pulsatilla fresh stems and leaves squeezed juice in the body (plating method) inhibition of Staphylococcus aureus Pseudomonas aeruginosa, after the removal of tannins lose its effect (and break the bowl flowers - autumn peony It still has this effect); the role of dysentery bacilli is poor, but it has also been reported that the effect of decoction on Shigella is different depending on the concentration of bacteria, and it has a stronger effect on Shigella. And the role of Song bacillus in turn reduced or not inhibit bacteria.
Pulsatilla sinica (Pulsatilla, Qinpi, Coptidis, Phellodendron) has neither synergistic nor antagonistic effects in the in vitro test of dysentery bacillus. Pulsatilla alcohol extract also has certain inhibitory effects on Bacillus subtilis and Staphylococcus aureus in vitro, and has no inhibitory effect on the growth of Mycobacterium tuberculosis in vitro, and has a mild inhibitory effect on influenza virus infection in mice. Some people have studied the effect of Pterocaryne (Anemonecernua) on pathogenic and non-pathogenic fungi in vitro. The results showed a slight inhibitory effect on a few fungi. The antibacterial active ingredient of Pulsatilla chinensis is Pulsatillae. Pulsatillae has an MIC between diphtheria, staphylococcus, streptococci, Escherichia coli, Mycobacterium tuberculosis, etc. between 8×10 (-5) - 2×10 (-6), Pulsatillae The antibacterial activity also has a synergistic effect with streptomycin.
4. Antiviral effect: Pulsatilla aqueous extract can prolong the survival date of influenza virus PR8 mice, and also slightly reduce the lung injury.
5. Other effects: It is reported that Pulsatillae ethanol extract has sedative, analgesic and anticonvulsant effects. The Pulsatilla chinensis that removes the roots has a strong heart ingredient okinalin, which acts like digitalis. Pulsatill anigricans produced in foreign countries has a sedative effect and can reduce blood pressure, slow down the heart rate, increase cardiac contraction, and increase gastrointestinal motility. Pulsatilla can still inhibit the germination of plant seeds. The pulsatilla saponin A3 contained in it had a certain anti-cancer effect, and the inhibition rate of P-388 was 100% at 53 μg/ml.
Pharmacokinetics
The cumulative excretion of fecal urine accounted for 10.6% and 10.8% of the dose after 24 hours of rats' po èŠ 550mg/kg, and 8.64% after 7 h of iv55mg/kg. %. Shows poor gastrointestinal absorption, mainly from the kidney
Excretion, fecal biliary excretion is small. After the dogs were iv11.25mg/kg, there was less discharge in the urine during the first 20min and 7h. After the dogs were iv11.25mg/kg, the urine output in the first 20min and 7h was 36.85% and 79.3% of the dose. Within 7h, the bile output accounted for 3.77% of the dose. The pharmacokinetic parameters after administration of Iv were: dogs T1/2a 6.29 min, T1/2B 1.33.4 min, K12 0.663 min-1, K21 0.0193 min-1, K10 0.0396 min- 1, Vd is 539.2 ml/kg, Cl is 3.14 ml/(kg min). Rabbit T1/2 was 5.92 min, T1/2 was 66.0 min, T12 was 0.0689 min-1, T12 was 5.92 min-1, K10 was 0.0349 min-1, and Cl was 6.11 ml/kg.min). The igCmax of 250 mg Paeoniflorin was 21.6 mg/L. The results showed that the plasma concentration-time curves of paeoniflorin in dogs and rabbits all met the two-compartment open model, which was widely distributed and eliminated quickly. After intragastric administration to rabbits, bioavailability in vivo was low.
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