Release date: 2014-05-06
A few days ago, researchers from the University of Pittsburgh used a thin sheet of material from the pig's bladder to help patients who had difficulty walking because of serious injuries on the battlefield and outdoor sports to re-grow their leg muscles. The research was published in the new issue of the journal Science Translational Medicine.
Under normal circumstances, human skeletal muscle can be regenerated after injury, but if the muscle is damaged a lot, it will not be self-repairing, and the unrepaired area will be filled by scar tissue, resulting in loss of tissue function.
Researchers have developed a new stem cell technology that induces stem cells to go to the injured site by implanting extracellular matrix (ECM) removed from the porcine bladder and inducing them to become muscle cells.
The researchers first performed animal experiments in mice with severely injured hind limbs, confirming that the new method was indeed effective before starting human clinical trials. The trial enrolled five patients, including three soldiers and two civilians, who lost 58% to 90% of their thigh or calf muscles due to an explosion or exercise. Surgery and other methods have no effect.
Before the operation, 5 patients were first treated with physical therapy for their respective functional defects, from 12 weeks to 16 weeks, and then surgically removed the scar tissue from the injured site and implanted the extracellular matrix, and restarted the physical therapy within 48 hours of surgery. It lasts from 5 weeks to 23 weeks.
After 6 months, all patients reported improved quality of life. MRI and computed tomography image analysis showed that the injured area of ​​5 people did form dense tissue after treatment.
Source: bio360
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