Researchers successfully deciphered the early warning network signal of liver cancer lung metastasis
February 27, 2018 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Professor Xia Jinglin from Zhongshan Hospital affiliated to Fudan University cooperated with Chen Luonan, a researcher at the Institute of Cell Biochemistry, Chinese Academy of Sciences, to lead Dr. Yang Biwei, Tang Wenqing and Dr. Li Meiyi. After 4 years of research, new discoveries have been made on the mechanism of liver metastasis of liver cancer, and the first successful application of dynamic network markers Methods The early warning network signal map of "before liver cancer lung metastasis" was screened and drawn. According to this figure, the dynamic changes of different stages of the disease course can be observed, which has important clinical value for the study of liver cancer lung metastasis. The results were published in the latest international core journal Nature Newsletter.
The metastasis and recurrence of liver cancer is the key reason for the survival rate. The lung is the most common site of liver cancer metastasis. The process and mechanism of lung metastasis of liver cancer in the world medical community are still unclear.
The research team used a high-transfer human hepatocarcinoma nude mouse model to detect gene changes in different stages of liver cancer lung metastasis using a genome-wide transcriptional expression profile chip, and found the third post-tumor transplant using the original dynamic network biomarker (DNB) method. Zhou is the critical stage of liver metastasis of liver cancer, and successfully identified and screened the core genes with early warning value for liver metastasis of liver cancer.
In order to further explore the mechanism of the dynamic network biomarker core gene in promoting the metastasis of liver cancer, the research team found the gene "CALML3" which plays a key role in the core gene. Based on the dynamic changes in the expression levels of CALML3 and interacting genes, the research team mapped out early warning network signals of “before liver cancer lung metastasisâ€. From this picture, it can be clearly seen that the third week (ie, early warning phase) changes before and after. The most obvious. At the same time, through the test of peripheral blood circulation tumor cells in nude mice model, it was found that a small amount of cancer cells appeared in the blood samples in the fourth week, indicating that cancer metastasis has occurred, further confirming that the third week is the critical (warning) stage before the occurrence of lung metastasis. It indicates that the development of lung metastasis of primary liver cancer is not a gradual change, but a sudden change point.
In the in vitro and in vivo experiments, the research team found that CALML3 has a significant inhibitory effect on liver cancer growth and lung metastasis. Among 270 patients with liver cancer resection, 114 cases of CALML3 were positive, and those with positive expression had a significantly higher survival rate than 156 cases with negative CALML3 expression, and patients with positive CALML3 expression had significantly lower recurrence and metastasis rate. In patients with negative expression.
The study found for the first time the inhibitory effect of CALML3 on liver cancer growth and lung metastasis. CALML3, as a tumor suppressor gene, is expected to become an early marker for liver metastasis of liver cancer and a new target for inhibiting liver cancer growth and lung metastasis. (Chou Yi, Sun Guogen)
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