American scientists have developed a "3D weaving" technology that can integrate vaccines of different doses into one body and release them multiple times after being injected into the human body, which is equivalent to the effect of multiple inoculations.
Many vaccines need to be vaccinated multiple times on a specific schedule to function, and it is easy to miss seeds due to lifestyle habits, medical conditions, and the like. The latest press release from the Massachusetts Institute of Technology says that the new technology can precisely control the release time of vaccines in different doses in the human body, and replacing multiple vaccinations with one injection is particularly meaningful for immunization work in developing countries.
The researchers reported in a new issue of the journal Science that they made a large number of tiny containers made of PLGA (polylactic acid-glycolic acid) polymer, packaged into a vaccine package, and injected into the human body to precisely control the degradation time of PLGA. Achieve multiple releases of the vaccine.
PLGA is a commonly used polymer material in medicine. It has good biocompatibility and can be safely degraded in living organisms. The degradation time can be precisely controlled by the molecular weight and structure of the polymer.
Researchers used photolithography to fabricate an array of molds containing about 2,000 cells on a glass plate. The PLGA "cups" in the mold can be layered and stacked like stacked wood to form 3D vaccine particles of different sizes. The researchers explained that this new "3D weaving" technology can make complex, sophisticated micro-devices. In contrast, traditional 3D printing technology is not suitable for such materials, and it is difficult to process tiny devices.
Experiments have shown that vaccine microparticles produced by this technique can remain stable in the body for a long time without leakage in advance, and the vaccine agent is released at a given time. The researchers designed particles that degraded at 9 days, 20 days, and 41 days after injection. After loading ovalbumin, they were injected into the mice. The protein was released as scheduled, triggering a strong immune response. The effect was comparable to the traditional method of multiple injections. .
The current particle size is too large, only suitable for subcutaneous injection, not for intramuscular injection. Researchers are looking to reduce particle size and further extend release time, hoping to eventually immunize multiple diseases with one injection.
Source: Technology Daily
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