Introduction: How to accelerate the drug development process? What kind of weapon can solve the bottleneck of drug development? How to develop modern new drugs in valuable and abundant natural medicine resources? The proliferation of macromolecules such as monoclonal antibodies, vaccines, and recombinant proteins is exploding. Do you expect to develop new drugs as soon as possible to occupy a place? Molecular Devices offers a complete solution for the most critical steps in the drug development process.
Drug screening is the testing and testing of preliminary pharmacological activities of substances that may be used as medicinal substances. For innovative drugs, screening is an indispensable means and approach. In particular, the competition for contemporary innovative drug research is very intense. The focus of competition lies in the screening of new drugs. Low-cost and high-efficiency screening of new drugs is the core of the problem. It is the process of shortening the discovery of new drugs. Molecular Devices is committed to providing innovative solutions for traditional small molecule and macromolecular drug development. Its products are known in the industry for its high throughput, cost saving, high automation, high stability, easy operation and use, and are recognized by the industry as a leader in high-throughput drug screening technology.
Monoclonal antibody drug development and screening
At different stages of antibody development, Molecular Devices offers a range of high-throughput, automated solutions ranging from microbial cloning to cell cloning screening and cell growth monitoring to address the most critical bottlenecks in antibody drug discovery.
There are two common methods for antibody drug screening: the first method is phage display. The construction of phage libraries and the direct screening of clones of human-derived antibody fragments specific for antigens from phage libraries has become a popular technique for antibody drug screening. In order to increase the success rate of screening for positive clones, the phage library usually constructed must have sufficient storage capacity. At present, the phage library can reach the storage capacity of 109–1011 clones. Screening the target clone from this huge library is no different from Shali gold. Therefore, an automated system is necessary to screen and manage the entire process. The QPix400 system is just right for this need, and it is currently the most professional microbial cloning screening platform. Phage library screening is also a major application direction of the QPix400 system.
The second method is the traditional hybridoma technique. Regardless of whether traditional mice or transgenic mice are used, the hybridoma technique first needs to immunize mice with the target antigen, and fuse the mouse spleen cells with the tumor cells to obtain a plurality of specific hybridoma clone libraries. However, finding a target antigen-specific hybridoma clone from a hybridoma cell bank is a time-consuming and laborious, but critical step. After obtaining candidate clones, in order to obtain a large amount of antibody protein, it is usually necessary to construct a stable cell line, which is an indispensable work in the development of antibody drugs. ClonePix screening technology avoids the use of limiting dilution, breaking the technical limitations of traditional methods, greatly improving the screening efficiency of hybridoma clones and stable cell line clones, shortening the screening time by half, and doubling the yield; screening 20,000 clones in 3 weeks, multi-project parallel , one step to find the clone you want.
In the process of screening cell clones, it is usually necessary to observe and detect the growth of the cells, and obtain data such as growth density, growth rate, and monoclonality of the cells. CloneSelect Imager can replace the manual, through the whole hole imaging, software automatically analyze to obtain objective cell growth data, and can be objectively verified whether it is a monoclonal.
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