A high-tech biopharmaceutical project with independent intellectual property rights – the production base of pregnant horses combined with estrogenic biopharmaceuticals, was recently established in Tuergen Township, Xinyuan County, Xinjiang. Its construction has broken the US monopoly of the international market and is the first biological product developed by Xinjiang itself. According to Gao Feng, deputy general manager of Teflon Pharmaceutical Co., Ltd., the industrialization base includes 2,000 pregnant horse standard farms, pregnant horse and urine collection points, pregnant urine rough extraction workshop, and plumbing power supply facilities. In part, it is planned to be completed in 3 years. After the base is put into production, it will break the monopoly of the United States in the maternity and estrogen-binding market. At the same time, it is expected that the Xinjiang herdsmen will increase their income by nearly 100 million yuan each year. Mammalian Estrogen Biopharmaceuticals is the extraction of unnaturally modified natural products from the urine of pregnant mares and the production of pure natural conjugated estrogens. This combination of estrogen is naturally non-toxic and has a good preventive effect on menopausal women's syndrome, osteoporosis and coronary heart disease. In 2002, the sales volume of this product in the United States alone reached US$1.2 billion, and it is growing continuously. However, production technology has always been monopolized by Wyeth-Alster Pharmaceuticals. This technology was first developed by a U.S. company in the 1940s and became a global monopoly technology. In 1998, Xinjiang Chemistry of the Chinese Academy of Sciences took the lead in extracting and separating conjugated estrogens from urine of pregnant horses. In 2000, Xinjiang Tefeng Pharmaceutical Co., Ltd. cooperated with them, transformed them into scientific and technological achievements, and improved various technologies to make them With the feasibility of industrial production. At the same time, new technologies for sustained-release preparations will be used to make sustained-release tablets in combination with estrogen drug substances. At present, these two core technologies have applied for patents for inventions, one of which has been approved and obtained national new drug certificates and production approvals. The implementation of this project will also greatly stimulate the local herdsmen to increase production and income. According to scientific and technical personnel surveys, if a mare measures 5 liters of urine per day, a mare can bring more than 2,000 yuan of income to herdsmen each year. According to statistics, Xinjiang currently has 350,000 mares. A pregnant horse discharges 3 to 4 liters of urine per day. The collection time is 150 days a year. Herdsmen can increase income from each mare by 2,000 yuan per year for 4 to 5 yuan per litre. Tefeng Pharmaceutical Co., Ltd. needs 20,000 tons of horse urine every year. According to the purchase price of horses and urine, it is calculated at around 4,500 yuan per ton. Xinjiang herders can benefit nearly 100 million yuan. Last year, the trial production of 1,000 horses that the company implemented in Xinliyuan, Xinjiang, has increased the herdsmen's income by 220,000 yuan. Research on the development of new raw materials and new preparations of pregnant horses combined with estrogens has won the National Key Project of the Tenth Five-year Plan for Science and Technology and the project of the “863†Plan. The project has passed provincial appraisal of scientific and technological achievements and has reached the leading level in the country. It is a scientific and technological achievement of great application value obtained through joint research of production, education, and research. In particular, the production of this product will break the international monopoly and greatly enhance the biological preparation of China. Level.
Monobenzone
Monobenzone can decompose melanin in the skin, and prevent the formation of melanin in the skin, used for the treatment of hyperpigmentation, such as various spots, age spots, melanoma. In addition as intermediates in organic synthesis.
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Function:
1.Monobenzone is a compound used as a topical drug for medical depigmentation.
2.The topical application of monobenzone powder in animals decreases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.
3.Monobenzone may cause destruction of melanocytes and permanent depigmentation.
4.The histology of the skin after depigmentation with topical monobenzone powder is the same as that seen in vitiligo.
5.The epidermis is normal except for the absence of identifiable melanocytes.
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