Every cell in the human body contains a complete DNA gene, which contains not only all the genetic information of the human body, but also the so-called methyl group in the gene is an essential component of human tissues. Researchers at the Jena Institute of Human Aging in Germany have confirmed for the first time that DNA errors and loss of methylation are an important cause of cancer. The findings were published in the latest issue of Nature.
Each tissue of the human body consists of tissue-specific cells of specific properties. Gene selection is very strict, as in the intestinal cells, only the corresponding gene list is activated to become intestinal cells. An important part of the gene regulation process is the so-called methyl group, which activates the gene through the action of an enzyme, which is called DNA methylation. When the body gets cancer or aging disease, the activity of normal gene fragments will be wrong, and the exact process and the role of DNA methylation have not been fully studied.
The function of DNA methylation as a gene-initiating "switch" (promoter) is well understood, but it is still unclear why methyl groups exist within a single gene (so-called genomic body). The research team led by Francis Nalley of the Leibniz Institute on Human Aging confirmed for the first time that when a methyl group is lost in the promoter of a gene, the gene will go wrong. The result is an abnormal protein that interferes with the composition of normal cells, causing large-scale destruction of cell function and identity, cell variability and possibly cancer, which is a mysterious process of DNA methylation.
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