Early diagnosis of pancreatic cancer is difficult and lacks specific drugs. Recently, researchers from France and Spain have found that a substance already used to treat anxiety disorders can interfere with the development of pancreatic cancer.
Pancreatic cancer is one of the most deadly tumors. At present, it is often treated by a general chemotherapy regimen. The Nupr1 protein belongs to the “intrinsic disordered proteinâ€. Scientists pointed out that it was involved in the development of pancreatic cancer as early as the 1990s. Now, scientists have discovered molecules that inhibit the activity of this protein.
Experts say the study screened molecules that effectively inhibit Nupr1 activity from more than 1,000 drugs that have been approved for the treatment of various diseases. Through the combination of computer simulation and pharmacological experiments, it can be known that this molecule can interact with Nupr1 protein, and its in vitro experiments show that it can reduce the ability of tumor cells to viable and metastasize, and completely inhibit the possibility of colony formation. The active compound has been tested for efficacy in animals and has been shown to prevent the development of the disease. This compound is trifluoperazine.
Trifluoperazine was previously only used as an antipsychotic drug in clinical practice, and it has been shown to be very effective against tumors. This study has made a new shift in the treatment of pancreatic cancer. Inhibition of Nupr1 may be a new therapeutic direction for the treatment of this cancer.
Https://medicalxpress.com/news/2017-02-pancreatic-tumor-antipsychotic-drug.html
Source: Noble
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