[China Pharmaceutical Network Technology News] Recently, a research report published in the international magazine Science, researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital are using a special method to detect a new type of HIV drug.
In the article, the researchers describe the detailed mechanism of action of immature HIV; HIV includes two forms: mature virus particles and immature virus particles, which are assembled in cells of infected individuals when they are immature. After the virus particles leave the cell, they must change to a mature form before infecting other individuals. Current researchers are conducting clinical trials on a new class of drugs that can inhibit the virus's maturation process, but so far scientists The mechanism of action of this drug is not clear.
In order to transition from maturity to maturity, HIV had to cut off the link between its main structural units and rearrange structural components; the researchers found an important cutting point that could connect to the virus. The capsid protein and spacer peptide, if not cleaved, the virus does not mature; the researchers used electron tomography and tomography to accurately reveal the 3D information of immature HIV, they found that Cutting points are often hidden in areas where the virus cutting machine does not work. Therefore, for the process of virus maturation, the structure must first change and the cutting point must be exposed.
Researcher Florian Schur said that when we used an inhibitory drug to observe the structure of the virus, we found that the inhibitor did not inhibit the cutting machine, and that the drug would lock the immature virus structure so that it did not Can be cut to make the virus mature. When this new inhibitory drug was developed, the researchers found that the inhibitor did not affect the HIV virus carrying a particular mutation, meaning that the virus was resistant to the novel inhibitor; The structure of the cutting point and the mechanism of action of the drug, the researchers clearly understand the effects of these mutations.
Researcher Krausslich said that the virus does not block the binding of the drug, but rather tolerate the drug by creating a special mutation that shakes the immature structure of the virus. Now we hope to further analyze the mechanism of action of viruses and inhibitory drugs, so as to more accurately understand how the inhibitory drugs are combined with viral proteins, providing new ideas for the later development of more precise drugs.
Using electron tomography and tomographic overlay technology, researchers can clearly study the internal structure of irregular viruses (such as HIV). Essentially, scientists can obtain 3D images of samples using electron microscopy, and then they All copies of the subject to be studied, such as capsid protein and spacer peptide 1, can be obtained. When researchers obtain a large number of microscopic images, they can conduct more in-depth research. The results of this study are for scientists to reveal the mechanism of HIV drug resistance, and to develop new and targeted HIV. New drugs may provide new research clues and ideas.
(In-depth study of the HIV drug mechanism will have new ideas in the later research. Source: Baidu Pictures)
In the article, the researchers describe the detailed mechanism of action of immature HIV; HIV includes two forms: mature virus particles and immature virus particles, which are assembled in cells of infected individuals when they are immature. After the virus particles leave the cell, they must change to a mature form before infecting other individuals. Current researchers are conducting clinical trials on a new class of drugs that can inhibit the virus's maturation process, but so far scientists The mechanism of action of this drug is not clear.
In order to transition from maturity to maturity, HIV had to cut off the link between its main structural units and rearrange structural components; the researchers found an important cutting point that could connect to the virus. The capsid protein and spacer peptide, if not cleaved, the virus does not mature; the researchers used electron tomography and tomography to accurately reveal the 3D information of immature HIV, they found that Cutting points are often hidden in areas where the virus cutting machine does not work. Therefore, for the process of virus maturation, the structure must first change and the cutting point must be exposed.
Researcher Florian Schur said that when we used an inhibitory drug to observe the structure of the virus, we found that the inhibitor did not inhibit the cutting machine, and that the drug would lock the immature virus structure so that it did not Can be cut to make the virus mature. When this new inhibitory drug was developed, the researchers found that the inhibitor did not affect the HIV virus carrying a particular mutation, meaning that the virus was resistant to the novel inhibitor; The structure of the cutting point and the mechanism of action of the drug, the researchers clearly understand the effects of these mutations.
Researcher Krausslich said that the virus does not block the binding of the drug, but rather tolerate the drug by creating a special mutation that shakes the immature structure of the virus. Now we hope to further analyze the mechanism of action of viruses and inhibitory drugs, so as to more accurately understand how the inhibitory drugs are combined with viral proteins, providing new ideas for the later development of more precise drugs.
Using electron tomography and tomographic overlay technology, researchers can clearly study the internal structure of irregular viruses (such as HIV). Essentially, scientists can obtain 3D images of samples using electron microscopy, and then they All copies of the subject to be studied, such as capsid protein and spacer peptide 1, can be obtained. When researchers obtain a large number of microscopic images, they can conduct more in-depth research. The results of this study are for scientists to reveal the mechanism of HIV drug resistance, and to develop new and targeted HIV. New drugs may provide new research clues and ideas.
VTM sampling kits are designed for the collection, preservation, and transport of viruses, chlamydia, mycoplasma, and ureaplasma urea. They are now widely used for sampling and transporting prior to virus detection. MandeLab's VTM kits provide a safe and convenient way to collect and transport virus samples.
Nasal swab kit virus sampling tube,Used to collect samples of secretions from the throat or nasal cavity, Disposable
Jiangsu iiLO Biotechnology Co., Ltd. , https://www.sjiilogene.com