Release date: 2015-12-24
According to a Japanese study, elastography-based magnetic resonance imaging (MRE) technology is more accurate than transient elastography (TE) in the classification of liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD).
"In our study, we have demonstrated that MRE and TE are a powerful diagnostic method for nonalcoholic fatty liver disease (NAFLD) compared to liver biopsy, but MRE is more accurate than TE for monitoring liver fat content and liver fibrosis. Dr. Atsushi Nakajima, Department of Gastroenterology, Yokohama City University Medical Research Institute, told Reuters Health News via email.
Dr. Nakajima explained that NAFLD is the most common liver disease worldwide, with 20% to 30% of NAFLD progressing to NASH and liver cancer. Liver biopsy is the NASH gold standard diagnostic method, but liver biopsy is "painful" and expensive, requires hospitalization, and may have complications such as bleeding. Establishing a non-invasive, simple diagnostic method for the diagnosis of NASH and NAFLD instead of liver biopsy is a very important issue in clinical diagnosis.
With this goal in mind, the research team did a cross-sectional study. The study included 142 patients with NAFLD diagnosed in Japanese liver biopsy and 10 patients without NAFLD. All 152 subjects used the M probe for TE evaluation (including controlled attenuation parameter (CAP) measurements), MRI used MRE and proton density fat fraction (PDFF) measurements, and five different clinical scoring systems.
"To our knowledge, this is the first study comparing liver and liver stiffness (LSM) in TE and MRE. Evaluation of fat accumulation based on TE-based CAP measurements, liver fibrosis and steatosis in patients with NAFLD confirmed by MRI-based PDFF assessment biopsy Situation. This study was published online on December 8, 2015 on Gastroenterology.
The researchers found that LSM obtained with MRE was "significantly positively correlated with the severity of liver fibrosis in patients with NAFLD." The study found that the diagnostic accuracy of MRE for liver fibrosis was significantly higher than the clinical scoring system and TE.
The AUROC curve value of patients with hepatic steatosis grade >2 diagnosed by TE-based CAP was 0.73, while the AUROC curve value of MRE PDFF to confirmed patients was 0.91 (P < 0.001).
The researchers said that the determination of serum K18 fragments or alanine aminotransferase did not increase the value of TE or MRI in identifying NASH.
"The MRE and PDFF methods are more diagnostic than the TE and CAP methods," said the investigators. "The non-invasive detection of liver fibrosis and steatosis in patients with NAFLD is more diagnostic than the non-invasive assessment of liver fibrosis and steatosis based on MRI. In practice it is a potential alternative to liver biopsy.
"Further research is needed to explore the prognostic value of the results of these diagnostic techniques to determine the long-term prognosis of patients with NAFLD," they added.
The Medical Forum Network was compiled from: Can Imaging Replace Liver Biopsy for NASH Diagnosis?December 18, 2015.Medscape.
Source: Medical Forum Network
Polybutyleneadipate-co-terephthalate PBAT
PBAT, a thermoplastic biodegradable plastic, is a copolymer of butanediol adipate and butanediol terethylphthalate. It has the properties of PBA and PBT. It has good ductility and elongation at break, as well as good heat resistance and impact performance. In addition, it has excellent biodegradability and is one of the most active biodegradable materials in biodegradable plastics research and market application.
Polybutyleneadipate-Co-Terephthalate Pbat,Thermoplastic Biodegradable Pbat,Flexible Packaging Pbat,Agricultural Film Pbat
Xingbang High Molecular Materials Co., Ltd. , https://www.chemicaladditive.com