Pharmacological effects
1 The role of the respiratory system with cough, expectorant and a slight asthma effect. In some parts of Eastern Europe, coltsfoot or leaf preparations are also used to treat bronchitis, pharyngitis and bronchial asthma. Injection of 1% iodine solution into the cat's right rib membrane was used to induce cough. Oral coltsfoot decoction had significant antitussive effect, but it was not lasting. Oral decoction in mice also has significant antitussive effect. Anesthetic cat oral decoction can increase respiratory secretion, but the strength is not as strong as Campanulaceae. Tracheo-pulmonary perfusion experiments in rabbits, guinea pigs, and cats showed that the extracts of the coltsfoot flower extract produced a slight relaxation of the bronchus, but contracted at high doses. For the histamine-induced caries, the spasm was not as effective as ammonia tea. Alkali does. Some people think that the nitrate contained in it is a cough suppressant ingredient.
2 Effects on the circulatory system: Anesthetized cats have an effect of decreasing the blood pressure and then increasing the alcohol extracts obtained by intravenous injection. According to the component separation test, the soluble fraction of coltsfoot is a pressure-increasing effect, and the alcohol-soluble ether is insoluble. The antihypertensive effect was preliminarily considered to be due to the effects of sympathetic ganglia excitement, sympathomimetic effects, central stimulatory effects, and direct vascular smooth muscle stimulation. Decoction and alcohol extracts showed inhibitory effects on isolated hearts. The ether extract showed contraction on both frog hindlimb and systemic vascular perfusion.
3 Other effects Ether extracts exhibited inhibitory effects on in vivo or ex vivo gastrointestinal smooth muscle. For isolated uterus, the alcohol extract is excited when in small amounts, and a large amount is excited after the first inhibition, or inhibited from the beginning. Coltsfoot leaf ether extracts and distillates also exhibit spasmolysis on isolated small intestine in rabbits.
1 Treatment of asthma
The coltsfoot flowers were made into alcohol extracts, 5 ml each time (equivalent to 2 raw herbs) and served 3 times a day. Observed 36 cases, including 21 cases of bronchial asthma, 15 cases of asthmatic bronchitis with emphysema. The results were markedly effective (1 to 2 days after taking the drugs, see asthma and cough, and the maximum flow rate in the mid-expiratory phase was significantly improved) in 8 cases, improved (the relief of cough for more than 3 days after taking the drug, or reduced but long-lasting unrest) 19 Example, invalid 9 cases. It has been observed that the Coltsfoot Alcohol Extract has an effect of relieving asthma, but its effect is weak and its long-term efficacy is not satisfactory. In the governance process, the more common reactions were nausea, a few or both upset and insomnia.
2 treatment of chronic bronchitis
The withdrawal coltsfoot and earthworms are processed into a compound coltsfoot injection, each time 2 ml is injected intramuscularly for 10 consecutive days. After treatment in 68 cases, 8 cases were clinically cured, 32 cases were markedly effective, 24 cases were improved, and 4 cases were ineffective. After initial observation of 3 to 4 injections, cough, expectoration, and wheezing were significantly reduced, appetite and sleep were also improved, and there was also a certain antihypertensive effect.
Coltsfoot [5] - Medicine (poison) Science
Coltsfoot flower extracts administered intraperitoneally to mice, guinea pigs and rabbits were injected intravenously, and frogs and frogs were injected into the lymphatic cavity, all causing convulsions and respiratory arrest. Oral alcohol extract of mice, the median lethal dose of 112g crude drug/kg, abdominal ether injection of 43g crude drug/kg. Toxicity: Half-lethal dose of Coltsfoot on mice, 124 g/kg with decoction, 112 g/kg with alcohol extract, and 43 g/kg with ether extract. Ether extracts are used in frogs, fleas, mice, rats, guinea pigs, rabbits, etc., and can cause irritability, respiratory excitement, muscle tension, spasms, and convulsions when intoxicated.
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