New method to restore congenital blind mice
August 17, 2018 Source: Guangzhou Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];American researchers have succeeded in reviving congenital blind mice with a new method, which has brought new hopes for the treatment of blinding diseases such as retinitis pigmentosa.
The research results were published in the journal Nature in the UK on the 15th. The author of the paper, Professor Chen Bo, professor of neurology and ophthalmology at Mount Sinai College of Medicine in the United States, said that the retina of the zebrafish has a self-repairing function. When the retina is damaged, the "Muller glial cells" can make the nerves of the retina. Cells regenerate, whereas mammalian cells do not have similar regenerative functions. Although the scientific community has been able to activate mammalian "Muller glial cells" by damaging the retina, this method is more harmful to the retina and is not conducive to restoring vision.
To this end, the researchers used gene transfer methods in mouse experiments to cause "Muller glial cells" to divide and develop into sensible rod cells. The newly developed rod cells are structurally indistinguishable from natural rod cells and form synaptic structures that allow them to communicate with other nerve cells in the retina. Experiments have shown that this method can restore the blind mice.
The study was funded by the National Eye Institute of the United States. Thomas Greenwell, director of the Retinal Neuroscience Program, said that this is the first time scientists have reprogrammed Miller's glial cells into functioning rods in the mammalian retina. Rod cells allow people to see things in dim conditions, and may also help protect cones, which are responsible for distinguishing colors and improving visual acuity. (According to Xinhua News Agency reporter Zhou Zhou)
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