For most people, the national gene bank has always been very mysterious. What it is like, what it can do, what it does, the outside world has not understood much.
We know more, just these:
In 2011, the National Development and Reform Commission approved the establishment of the Shenzhen National Gene Bank based on the Shenzhen Huada Life Science Research Institute (formerly known as Shenzhen Huada Genetic Research Institute). In October of the same year, the construction plan of the Shenzhen National Gene Bank (hereinafter referred to as the National Gene Bank) was approved by the National Development and Reform Commission, the Ministry of Finance, the Ministry of Industry and Information Technology, and the former Ministry of Health.
Genetic resources are the strategic resources of the country and play an important role in national health, ecological protection and bio-industry development. The continuous breakthrough of gene sequencing technology has brought about major changes in the field of life sciences. The development and utilization of genetic resources will occupy the strategic high ground of the future development of the global bio-industry chain.
At present, developed countries such as Europe, the United States and Japan have included genetic resources reserves in strategic plans. The government has invested heavily in the establishment of national gene banks (EBI, NCBI and DDBJ) and continues to provide substantial financial support.
In the past decade, the output of genetic data in China has doubled. However, due to the lack of a reliable data platform, it is difficult to fully and effectively develop and utilize a large number of biological genetic data with unique Chinese populations, posing a huge potential threat to the safety of genetic resources in China. Building a national gene bank has important strategic significance.
The national gene bank is constructed in two phases. The first phase is located in Hetangzi, Xiasha District, Dapeng Street, Dapeng New District, Shenzhen, with a construction area of ​​47,500 square meters.
Now, we can finally have a more comprehensive and detailed understanding of it.
Recently, Huada Gene Organization Media Open Day, Xu Xun, CEO of Huada Group, Executive Director of the National Gene Bank, and Dean of the Huada Gene Research Institute, introduced the national gene bank to the media.
The following are the main information disclosed by Huada Gene Executives:
The national gene bank is world-leading.
The National Gene Bank is not only world-leading in its size, structure, layout and content.
First, the level of construction of biological sample resources is leading the world. In terms of storage scale, more than 20 million tubes of blood, tissue, body fluids, seeds, microorganisms and other biological resources have been stored. In terms of coverage, a special germplasm resource bank, a human symbiotic microbial strain resource pool, and environmental microorganisms have been initially established. Characteristic library such as strain resource pool and large population genetic resource library has become the largest comprehensive biological resource sample database in the world.
Second, the level of genetic information database construction is leading the world. In terms of storage capacity, it has 60PB data storage capacity, and achieves access to 500PB of genetic information data. The data storage capacity has surpassed the three major gene banks in the United States, Japan and Europe.
Third, scientific research is fruitful. Since its inception, it has published 150 papers based on the national gene bank platform, including 55 papers published in the field's top journals GCNNS (Giga science, Cell series, Nature, New Engl J Med, Science and journals). There are 39 foreign patents and 12 software copyrights. At the same time, the National Gene Bank, as an important participating unit, participated in the second super-significant international cooperation project in the global genetic field--"Synthetic Yeast Genome Project".
The fourth is to support the service level. As a national platform, the National Gene Bank provides effective support for the bio-health industry and rapid bio-economic development based on its platform advantages of “storing, reading and writing†and the resource advantages of large samples and big data. At present, it has formed cooperative relations with more than 100 institutions at home and abroad, and has formed and joined more than 50 international alliance organizations, initially forming a global alliance system. As a technical counterpart of the International Standards Organization (ISO) Biotechnology Standards Committee (ISO/TC276) in China, the National Gene Bank will strive to enhance China's voice in the field of biotechnology; at the same time set benchmarks to lead the industry development, standardization The process accelerates the development of the bio-industry. The National Gene Bank has published 14 national, group, local, and corporate standards, and 2 international standards.
The fifth is the initial results of the open sharing system. The National Gene Bank has initiated the establishment of a national gene bank resource information sharing service platform. At present, more than 30 sample depositories have participated in the open sharing of sample information of the national gene bank, and the total amount of sample resource information has reached more than 600,000 copies. The National Gene Bank has built more than 40 bioinformatics databases and data analysis platforms, such as the Millet Database, Thousand Plants Transcriptome Database, Million Pathogen Identification Database, Cancer Data Integration and Integration Analysis Platform, which can be retrieved up to 8.8. Billion, integrated more than 1.5 species (variety), 44,000 samples, 550 million sequences, 10 million genes, 300 million mutation information, associated 1PB downloadable data, professional access The volume exceeded 118 million.
The strategic significance of building a national gene bank
First, it is conducive to the protection and full use of China's unique genetic resources. Building a national gene bank is conducive to maintaining China's bio-information security, improving the storage, analysis and management capabilities of China's genomic data, promoting the sharing and utilization of genetic and data resources, and enhancing the international discourse power in China's life science big data era. It is of great strategic importance to develop the bio-industry, seize the strategic commanding heights of the future bio-economy, and control the strategic resources of genes. The National Gene Bank will fully integrate the resources of all parties to form a cooperative and exchange mechanism with outstanding features, open platform and resource sharing, improve the rationality, legitimacy and maximum resource conversion of sample resources, and support people's livelihood, medical health and scientific research. Promote the achievements of bio-innovation technology.
Second, it is conducive to improving the innovation ability and information sharing degree of China's life sciences. Actively implement the strategic plan of the 19th National Congress on "Accelerating the Construction of an Innovative Country". The National Gene Bank will build a public service platform for genetic information resources, create a sustainable new gene library system, and support scientific research institutions to dig deep into genetic information data. Explore new frontiers in areas such as management, medical and health, environmental transformation, and agricultural production, expand new disciplines, achieve new breakthroughs, continuously improve China's life science innovation capabilities, and accelerate the storage of resources through the integration of large projects, big science, and big data. The cycle of basic scientific research to technology transformation and application promotes the transformation of genomics into clinical medicine, molecular breeding, reproductive health and other fields, and continuously promotes new technologies, new products and new models in the field of big health, and promotes the rapid development of related industries. The development of industry and the enhancement of scientific and technological innovation capabilities will play a huge role in promoting.
National Gene Bank will promote the development of precision medicine
Life, health, resources, and big data are the cornerstones of precision medical development. For example, the identification of individual tumor biomarkers and their application to the diagnosis, prognosis and efficacy prediction of diseases has a very important impact on precision medicine, and it also rapidly changes the clinical treatment methods. The screening of biomarkers related to these diseases depends on a large number of The complete biological sample and data information is based on information.
The National Gene Bank provides a strong support for the storage of massive vital resources and data. The National Gene Bank will establish an open and shared resource pool around maternal and child health, health and aging, cancer, microbes and other resources to provide stable, reliable, high-quality, standardized sample resources for medical research, and rapidly transform and apply research results to the clinic. The realization of translational medicine provides important support. The National Gene Bank will also rapidly promote the construction of domestic automated biological sample banks, responding to the rapid growth of sample volumes in the tens of millions of levels each year, to meet the needs of precision medical and large-scale population cohort research.
The National Gene Bank will also build the ability to calculate and analyze very large data, which will be the core key technology platform in omics and precision medicine. The bioinformatics database will promote the research model of biodata, make the value of stored data play, and build tools and applications for data sharing and data mining based on vast amounts of data, information and knowledge.
In terms of gene big data analysis and mining, the National Gene Bank database will collect and organize the data of all stages and levels of life, connect data storage with data applications, realize data sharing, and realize it in new scientific hypothesis. It is constantly being re-excavated by new technologies, bringing qualitative leap to life health, modern wisdom agriculture, medical diagnosis and treatment, benefiting people's livelihood, accelerating the implementation of "precise medical care" and promoting the transformation of medical diagnosis and treatment mode. In the future, we can also realize the research and application of various aspects of origin evolution, genetic diseases and precision medicine.
Based on the world leading ability of gene sequencing capability and ultra-large-scale bioinformatics analysis and computation, the high-throughput low-cost synthesis and editing platform of the national gene bank construction will serve as a public service platform and will fully support the global genome in terms of technology and production capacity. Cross-application exploration in the fields of learning, industry, agriculture, medicine, etc. Gene synthesis and editing technology common breakthroughs in key biotechnology will fully support the cutting-edge exploration of precision medicine, and promote new technologies, new products and new models.
Author: Lin Yan
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