Traditional clinical drugs enter the human body, how to monitor and evaluate the targeted effects? Today, this problem is expected to be resolved. The reporter learned on the 2nd that scientists from Tianjin University have used nanotechnology to develop new types of nanoparticles by adding rare earth materials, which are expected to solve the defects of traditional pharmaceutical preparations and achieve targeted observation and visualization of targeted drugs. Related research results are among the top in the field of nanotechnology. Published by ACS Nano.
Tianjin University’s School of Life Science Professor Chang Jin’s team has long been dedicated to the basic and applied research of nanobiotechnology in the diagnosis and treatment of major diseases such as cancer. In the research, they used bio-additive technology to construct a multi-functional rare earth up-conversion nanoparticle, and successfully prepared a protein mineralized antimony-doped copper sulfide nano-diagnosis agent. The new type of indium copper/zinc sulphide nanoparticles for photothermal therapeutic use has an inherent photothermal effect and photodynamic effect under 660 nanometer laser irradiation, thereby obtaining a high antitumor therapeutic effect.
On this basis, the researchers combined the PET imaging technology with the optical imaging technology, and for the first time explored and constructed a copper 64-labeled indium copper/zinc sulfide quantum dot, and tested the relevant physical and chemical properties with the help of tumor-tolerant mice. . The experimental results show that the yttrium-doped copper sulfide nano-particles have excellent photoacoustic and MRI imaging effects, and can play a very good visual guiding role in photothermal therapy. The nanoparticle has excellent PET imaging and optical imaging properties, and can successfully convert near-infrared light that can penetrate deep tissues into local blue light, thereby activating intracellularly-controlled light-inducing proteins and achieving multi-target sub-targeting of proteins. Cell location and cancer treatment. This study not only provides a new direction for the visualization of PET guided nanomedicine, but also opens up new ideas for the implementation of minimally invasive optogenetics technology in vivo.
The above research work has also been supported by the National Key Research and Development Program of the Ministry of Science and Technology, the National Natural Science Foundation of China, and the Natural Science Foundation of Tianjin City. (Reporter Sun Yusong’s correspondent Zhao Xi钧)
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