Release date: 2017-02-21
On February 2, 2017, Cell published a research paper by David M. Sabatini, a researcher at the Massachusetts Institute of Technology, and a researcher at Eric S. Lander, who reported 14 human acute myeloid leukemia (AML) cells. A group of key genes that are required for cell proliferation and survival. Combining this "gene necessity map" with existing genomic information will help in the development of new therapies.
In this study, the researchers focused on the genes and protein pathways associated with the Ras oncogene. The Ras gene is an oncogene that is frequently mutated in human cancer and plays an important role in acute myeloid leukemia and other cancers.
Tim Wang, the first author of the paper, said: "In most cases, mutants of the Ras protein are considered to be 'undruggable'. However, the alternative is to find other genes that the Ras mutant is dependent on, I hope that one of them will become a drug target. Unfortunately, this 'Ras synthesis lethal' gene is still difficult to determine."
Using CRISPR-based genetic screening technology, the researchers used a comprehensive assessment of the impact of 18,000 protein-coding genes on the human genome. Analysis of these data and subsequent work revealed the molecular function of previously unrecognized genes and identified lethal interactions with Ras mutants. David Sabatini, senior author of the paper and MIT, said: "This process allows us to identify the list of genes necessary for Ras mutant cells."
Source: Biological help
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