Release date: 2017-07-03
A new study published in "Cell" on March 23 (click on the bottom left corner to read the original text), remove the "retired" cells in the body can eliminate the damage caused by aging, which brings hope to the new life extension treatment .
The researchers used a substance to treat mice that cleared cells that went to sleep due to DNA damage. The treated mice were regenerated and their kidney function improved, running twice as long as untreated mice.
The team is evaluating whether the lifespan of these mice has also been extended, and plans to conduct a series of safety studies in humans with the ultimate goal of testing whether these so-called aging cells can reverse some of the aging-related diseases.
This discovery makes it possible for doctors to treat aging itself in the future, rather than dealing with various diseases that come with aging.
Peter de Keizer, a 36-year-old scientist at the Erasmus University Medical Center in the Netherlands, said that this seemingly sci-fi scene has been scientifically supported. He said: "Maybe when people reach the age of 65, they go to the clinic every 5 years. Aging injection. I think it can be achieved when we reach this age."
As we age, DNA damage accumulates in cells, and beyond a certain threshold, it can no longer be repaired. At this point, the cells will become cancerous, self-destructive or enter a semi-dormant state. People initially thought that these aging cells were only neutral bystanders, without any biological function, but also harmless.
However, about a decade ago, this view changed.
De Keizer said: "These aging cells produce a lot of rubbish and have a negative impact on the body." He likens these cells to students in the classroom who are disturbed by the students.
In the photo are two fast-aging mice. The mice on the left were treated with the FOXO4 peptide, and the hair of these mice re-grows within ten days. On the right is a mouse that has not been treated.
There is growing evidence that aging cells are associated with geriatric diseases, which are higher in arthritic joints, cataracts, and plaque-producing arteries.
A study published last year showed that the use of genetic methods to remove these cells increased the lifespan of mice by an average of 20%. The most recent paper is the first to show that not only can aging be removed by removing senescent cells, but it can even reverse aging.
In this study, scientists awakened aging cells from dormancy and put them into death.
The researchers used two mice, one that was naturally aging, and the other that had been genetically engineered to rapidly senescence, injecting them three times a week for FOXO4 peptide over a 10-month period.
The researchers initially wanted to evaluate kidney function, but a laboratory technician pointed out that some hair-shed mice re-extended new hair.
These mice are no longer so lazy, but start to walk around and explore their cages.
Rapidly aging hair removal mice began to regenerate new hair 10 days later. After three weeks, various health improvement conditions began to appear. These treated aging mice beat twice as long as the untreated mice. One month later, the kidney function of these mice was also improved.
The study suggests that in the future, this method of removing aging cells from the body may prevent damage from aging. But before scientists can determine that the drug can help humans prolong their lives, they still need to do a lot of testing.
But there are still problems with the limitations of this technology: not all tissues are renewable, which means fewer cells will be left behind. De Keizer said: "I am worried that removing these cells will cause the mice to shrink inward." He added that he did not find signs of atrophy, but it is still a problem that must be considered.
The team plans to conduct a human safety clinical trial in which the subject is a pleomorphic glioblastoma patient in which the cells are similar in characteristics to senescent cells, making the FOXO4 peptide possible to treat the cancer.
Juan Carlos Izpisua Belmonte, a scientist at the Salk Institute, recently published a study that pointed out that aging may be reversed. He said: "I think the method of removing senescent cells may enter clinical trials in the next few years. The peptides like FOXO4 are almost ready for clinical trials."
Source: China Biotechnology Network
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