Incompatibility
Antibacterial drugs: licorice and its preparations contain glucocorticoids, high-dose licorice combined with tetracycline, erythromycin, chloramphenicol and other antibacterial drugs can reduce the absorption rate of these drugs, such as long-term compatibility Can cause double infection. Licorice also avoids long-term compatibility with isoniazid and amphotericin B to avoid the increase of drug side effects. The bacteriostatic effect of berberine and licorice was decreasing. In addition, there are clinical reports that antibacterial and anti-inflammatory cephalexin tablets are used together with licorice mixture with antitussive and expectorant effects, resulting in reduced antibacterial activity of cephalexin tablets.
Salicylic acid and non-steroidal anti-inflammatory, anti-pyretic, analgesic: Glycyrrhizic acid contained in licorice can be hydrolyzed into glycyrrhetinic acid and glucuronic acid by the action of enzymes. The structure of glycyrrhetinic acid is similar to that of adrenal glucocorticoids. If combined with salicylic acid derivatives, the rate of ulceration in the digestive tract can be increased. It has been reported that the combination of compound licorice tablets and aspirin will increase the area of ​​original duodenal ulcers in patients, leading to increased upper abdominal pain and upper gastrointestinal bleeding. This is because aspirin has a stimulatory effect on the mucosa of the digestive tract, and it should be used with caution in patients with original ulcers. Glycyrrhizic glucocorticoid-like effects, combined with aspirin, can increase the stimulation of the digestive tract, it should not be combined in the use of drugs.
Hypoglycemic agents: Oral hypoglycemic agent tolbutamide, hypoglycemic spirit, glibenclamide, insulin, etc. If used in conjunction with licorice can reduce the effect of hypoglycemic agents. Because glucocorticoids can transfer amino acids and proteins from skeletal muscle to the liver and increase the production of glucose and glycogen under the action of related enzymes, they can increase blood glucose. Glycyrrhiza has a glucocorticoid-like action, so it is pharmacologically antagonistic to hypoglycemic agents. It has been reported that Jiangtang Ling and glycyrrhizin tablets served together to increase blood glucose and worsen the patient's condition. This is because glycyrrhizin can affect the hypoglycemic effect of Jiangtangling. In addition, glucocorticoid-like effects of licorice can also increase liver glycogen and increase blood sugar.
Cardiotonic drugs: licorice has a deoxycorticosterone-like effect, sodium can discharge sodium, so that the body of potassium decreased, leading to increased cardiac sensitivity to cardiac palpitations, resulting in poisoning. Clinically there are Zhigancao and digoxigenin tablets in the same service, patients with early morning and second-order law, a joint law report. This is due to the fact that licorice can cause hypokalemia, and it can easily induce digitalis poisoning reaction with digoxigenin tablets. Should avoid the combination of the two or appropriate potassium supplement when combined.
Diuretics: The glucocorticoid-like action of licorice protects sodium from potassium. If combined with potassium diuretics such as hydrochlorothiazide, uric acid, furosemide, chlorthalidone, acetazolamide, etc., the serum potassium ion concentration can be reduced, it is easy to aggravate the risk of hypokalemia, increase adverse reactions, such as edema, Increased pressure, general weakness, and even severe hypokalemic paralysis can occur. Clinically, compound licorice tablets and hydrochlorothiazide tablets were taken together, resulting in increased edema and urinary retention. The reason is that glycyrrhetinic acid has a row of potassium, can cause hypokalemia, hydrochlorothiazide tablets can also accelerate the excretion of potassium ions, so the combination of the two can cause hypokalemic edema, urinary retention. Potassium supplements should be avoided when they are used together or in combination.
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